6.48. The assessment time frame is often kept fixed throughout the various iterations of safety assessment. In other cases, however, it may be necessary to revise the assessment time frame between different iterations of safety assessment to reflect new information gathered. For example, it might be considered necessary to extend the time frame to ensure that the maximum or peak dose is covered within the assessment calculations. This could be necessary if new information indicates that the waste would contain greater amounts of long lived radionuclides than previously assumed. Alternatively, it might be considered appropriate to restrict the time frame for quantitative assessments to periods over which the results of safety assessment are meaningful, given the uncertainties. As an alternative to limiting the time frame of the assessment, the emphasis put on quantitative results for the later part of the time frame could be reduced. However, in all such cases, the impacts beyond the period of quantitative assessments should be addressed in an appropriate manner in the safety case.