4.77. In general, the safety case for each stage of planning and development of the disposal facility will include all of the different evidence, arguments and analyses that are available to support the assessment of the quality and performance of the disposal facility. Findings that are in contradiction to arguments made in the safety case and uncertainties should also be discussed and analysed. This necessitates a detailed discussion of the following: @@- The treatment of uncertainty in the safety case and supporting assessment;@@- The quality and reliability of the science and the design work that form the basis for the safety case;@@- The quality and reliability of the safety assessment, including the development of each scenario, the adequacy of the range of scenarios considered, assessments of their likelihood, and the adequacy of the methods, models, computer codes and databases used;@@- Management system requirements on the performance of safety assessment calculations to provide assurance of their quality.