4.24. The approach to demonstration of safety should also set out explicitly how the management of uncertainties will be addressed in the safety case. This should cover, as a minimum, how uncertainties will be identified, how they will be characterized and what the approach will be to their management. Specific recommendations on the management of uncertainties are provided in Section 5. The safety principles adopted should reflect those established in Ref. IAEA Fundamental Safety Principle (2006), with particular reference to Principle 7 on protection of present and future generations: “People and the environment, present and future, must be protected against radiation risks.” The regulatory criteria will be established by the regulatory body and, as a minimum, need to address radiation dose and risk constraints for workers and the public (both present and future generations), and protection of the environment. They need to cover the normal evolution of the facility and disturbing events- both events of natural origin and human induced events such as human intrusion into the facility. Internationally agreed criteria covering these aspects are set out in Ref. [IAEA No.SSR-5 (2011)].